Familial adenomatous polyposis : clinical presentation, detection and surveillance
| Journal | Volume 74 - 2011 |
| Issue | Fasc.3 - Symposium |
| Author(s) | S. Laurent, D. Franchimont, J.P. Coppens, K. Leunen, L. Macken, M. Peeters, O. Plomteux, M. Polus, B. Poppe, C. Sempoux, S. Tejpar, M. Van Den Eynde, A. Van Gossum, J. Vannoote, A. Kartheuser, E. Van Cutsem |
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| (1) Belgian Polyposis Project, Familial Adenomatous Polyposis Association (FAPA) , Brussels ; (2) Treasurer of the FAPA, Digestive Oncology, Ghent University Hospital, Gent ; (3) Vice-President of the FAPA, Gastroenterology, Erasme University Hospital, Brussels ; (4) Board Member of the FAPA, Clinique Notre Dame de Grâce, Gosselies ; (5) Board Member of the FAPA, Gynaecologic Oncology, University Hospital Gasthuisberg, Leuven ; (6) Board Member of the FAPA, Gastroenterology, University Hospital Antwerp, Edegem ; (7) Antwerp University Hospital, Oncology, Edegem ; (8) Board Member of the FAPA, Gastroenterology, CHC - Clinique Saint Joseph, Liège ; (9) Board Member of the FAPA, Gastroenterology, CHU of Liège, Liège ; (10) Center for Medical Genetics, Ghent University Hospital, Gent ; (11) Board Member of the FAPA, Department of Pathology, Cliniques Universitaires St-Luc, Brussels ; (12) Board Member of the FAPA, Digestive Oncology Unit, University Hospital Gasthuisberg, Leuven ; (13) Board Member of the FAPA, Oncology, Cliniques universitaire Saint-Luc, Bussels ; (14) Board Member of the FAPA, Gastroenterology, Erasme University Hospital, Brussels ; (15) Board Member of the FAPA, Digestive Oncology Unit, University Hospital Gasthuisberg, Leuven ; (16) General Secretary of the FAPA, Colorectal Surgery Unit, Department of Abdominal Surgery and Transplantation, Cliniques Universitaires St-Luc, Brussels ; (17) President of the FAPA, Digestive Oncology Unit, University Hospital Gasthuisberg, Leuven. |
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Colorectal cancer (CRC) is a leading cause of cancer related death in the western countries. It remains an important health problem, often under-diagnosed. The symptoms can appear very late and about 25% of the patients are diagnosed at metastatic stage. Familial adenomatous polyposis (FAP) is an inherited colorectal cancer syndrome, characterized by the early onset of hundred to thousands of adenomatous polyps in the colon and rectum. Left untreated, there is a nearly 100% cumulative risk of progression to CRC by the age of 35-40 years (1,2), as well as an increased risk of various other malignancies. CRC can be pre- vented by the identification of the high risk population and by the timely implementation of rigid screening programs which will lead to special medico-surgical interventions. (Acta gastroenterol. belg., 2011, 74, 415-420). |
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© Acta Gastro-Enterologica Belgica. PMID 22103047 |
